International Journal of Natural Medicine and Health Sciences

A comprehensive Review on Phyto-Pharmacological Potential of Justicia adhatoda

Sun, 30 Jun 2024 00:00:00 +0000

Herbs have always been a source of new medicine since ancient times. Consequently, the use of alternative medicines such as herbal products has been increasing over the last decades gaining popularity among the public and health care professionals. The Justicia adhatoda L. is a species of the Acanthaceae family, an iconic native plant of the Indian subcontinent. It is mentioned for its traditional use in the WHO basic health care guidelines. Primarily it is used to treat a variety of ailments in the alternative system of medicine. The plant possesses a substantial number of phytochemicals such as alkaloids, triterpenoids, flavonoids, proteins, carotene, amino acids, and vitamin C, found in roots and leaves like vasicine, vasicoline, vasicinone, adhatodine, vasicolinone, and anisotine exhibiting diverse pharmacological effects. A few of the chronic medical conditions that are treated by Justicia adhatoda include bronchodilator, anti-microbial, hepatoprotective, anti-asthmatic, antibacterial, anti-arthritic, anti-inflammatory, cardioprotective, anti-cancer, and anti-allergic actions. The chief phytochemicals of the plant are vasicine and vasicinone, which have the major therapeutic effect of treating respiratory disorders. Hence this medicinal plant could be the source of new therapeutic drugs in the future.

Sonographic correlation of umbilical cord and umbilical vein diameter with fetal weight

Sun, 30 Jun 2024 00:00:00 +0000

Estimating fetal weight is an important step for smooth and easy delivery the fetus, as approximation of fetal weight is necessary to plan the mode of delivering the baby thus facilitating the process both for the mother and the child. To correlate the method of predicting weight of the fetus by umbilical cord and its vein diameter. It was a cross sectional analytical study directed at The University of Lahore Teaching Hospital. The study was taken place for 12 months for which 200 women in their antenatal period were recruited. Convenient sampling technique was used and surveyed up to the date of delivery for actual weight at time of the birth. Paired t-test and the regression analysis was applied. The study concluded that the umbilical cord and the vein diameter serve as the major contributory factors in the fetal weight estimation by sonographic method. These methods are more accurate and easier as compared to the other methods implemented in the clinical practice until a few decades ago. Therefore, there is a need that clinical practices are modified and fetal weight estimates are done by using the umbilical cord and vein diameter to achieve better health outcomes for both mothers and children by pre planning the delivery method based on weight estimation of fetus

Association of sacroiliac joint pain and its dysfunction in patients with low back pain

Jawad — Sun, 30 Jun 2024 00:00:00 +0000

This study aims to figure out how many people with low back pain have pain and dysfunction
in the sacroiliac joint, how much it affects their daily lives, and the relationship between pain
and dysfunction in the sacroiliac joint in people with low back pain. The study was crosssectional. A sample of 357 people was used to collect the data. Information was gathered
through Segment Self-organized poll, Denver SI Joint Survey and Visual Simple Scale and
furthermore composed informed agree were given to the members. Information was broken
down utilizing SPSS form 23. The majority of the 357 participants were over the age of 45
(37.5%), and only 12% were between the ages of 15 and 25. Both sexes were almost equally
involved. The majority of the participants were severely disabled (49%) with moderate pain
(43.4%), and only 7 were bed bound. One of the most common causes of low back pain is pain
in the sacroiliac joints. According to the findings of the study titled "Association of sacroiliac
joint pain and its dysfunction," the majority of patients have moderate pain and dysfunction
that falls into the "severely disabled" category. The highest proportion of the affected
population is over 45 years old, with almost equal participation from both genders.

Strychnos nux vomica, a traditional phytomedicine for nervine & joint disorders: A short review

Syed Faisal Zaidi, Muhammad Matee-Ur-Rehman, Fakhri Ahmad, Muhammad Danial — Sun, 30 Jun 2024 00:00:00 +0000

Strychnos nux-vomica L. (Strychnine tree) is from the genus Strychnos of the family Loganiaceae. It is a medium sized tree with white flowers and 3 nerved leaves. Traditionally, Unani/Eastern Medicine (EM) physicians have used it for hundreds of years. According to the philosophy of EM, it is used in phlegmatic diseases like paralysis, facial palsy, ptosis, gout, joint pain, sciatica etc. It is used as a single medicine as well as in compound formulations. This article is focused to elaborate its uses in nervine and joint disorders. Scientific databases including, PubMed, Elsevier and Google scholar were explored for the research. Articles were included from 2008 to 2023 in the above-mentioned search engine. Different key words used were “Azaraqi”, “Strychnos nux vomica”, “Sciatica”, “arthritis”, “nervine disorders”, and “joints disorders”. Strychnos nux vomica as an individual drug and its combination with other drugs as a compound medicine can be used in treatment of facial palsy, epilepsy, gout, arthritis, rheumatoid arthritis, cervical spondylosis, and sciatica. It was also found that the species has promising anti-inflammatory, anti-convulsant, anti-arthritic, anti-epileptogenic, and anti-oxidant activities. Additionally, it can also help in the regeneration of damaged nerve. From this study, it can be concluded that Strychnine tree can be a leading candidate in treating different nervine and specially, joint disorders which is supported by case studies. However, more mechanistic evidence and research through in-vitro, in-vivo, and clinical studies are required particularly for joint disorders

The c.677C>T polymorphism in the MTHFR gene associated with hypothyroidism

Hafsa Tahir, Akhtar Ali, Hira Babar — Sun, 30 Jun 2024 00:00:00 +0000

Methyl tetrahydrofolate reductase (MTHFR) catalyzes the formation of tetrahydrofolate from folate. Mutation in the MTHFR gene may be the potential cause of hypothyroidism. We aimed to assess the genetic association of c.677C>T and c.1298A>C polymorphisms in the MTHFR gene with hypothyroid and hyperthyroid conditions. We registered 100 participants; 50 were clinically diagnosed with thyroid dysfunction and a control group of 50 individuals. All the samples were analyzed for serum TSH, T3, and T4 values. DNA was extracted and PCR was carried out to amplify exon 4 and 7. Restriction fragment length polymorphism (RFLP) was performed for genotype C677T and A1298C alleles and confirmed by sequencing. Serum values confirmed that 32/50 patients were with hypothyroidism and 18/50 with hyperthyroidism. Genotyping data showed no deviation from Hardy-Weinberg equilibrium in the three groups. The c.677C>T polymorphism was found significantly associated (pvalue=0.021) with hypothyroidism while no significant association (p-value=0.365) with hyperthyroidism. The genotype data of allele c.1298A>C showed no significant association with hypothyroidism (p-value=0.324) and hyperthyroidism (p-value=0.303) patients. This study concludes that c.677C>T polymorphism in the MTHFR gene is possibly associated with hypothyroidism in Pakistani thyroid disease patients and can be a potential genetic marker for early risk assessment.