Antibiotic resistance trends in UTI-causing E. coli
DOI:
https://doi.org/10.52461/ijnms.v4i1.2973Abstract
The aim of this study was to find out the prevalence of multi-drug resistance E coli in urinary
tract infection patients visiting the General Medicine Department at Pakistan Institute of
Medical Sciences. During the course of six months, a total of eight hundred urine samples
were taken from both indoor and outdoor patients attending the PIMS laboratory. Of these
samples, 150 tested positives for urinary tract infections. After that, these samples were
examined utilizing various culture media. Urine samples were cultured on CLED Agar media
to determine the presence of bacteria, and then the biochemical test API 10, which is often
used to identify gram negative bacteria, was performed. After bacterial growth was observed
in the samples, MHA medium was added to determine the antibiotics' sensitivity or
susceptibility using an antibiotic disc. Following that, the results were documented, with over
three medications exhibiting resistance to the tested antibiotics being ruled out as MDR. Fifty
samples were not MDR, while 100 out of 150 samples were positive for MDR.
Amoxicillin/clavulanic acid (74.7%), Cefepime (70%) and levofloxacin (62.7%) exhibited the
highest resistance among the agents tested, whereas Fosfomycin (15.3%), amikacin (16%) and
tazobactam (18.7%) showed the lowest resistance. The other examined medicines in the
current investigation included ceftriaxone 43.3%, ampicillin 54%, cefepime 70%, sulbactam
24.7%, and cotraimaxloe 47.3%. Resistance to norfloxacin is 54% and Fosfomycin is 15.3%,
respectively
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