Fabrication and characterization of curcumin loaded ZnO nanoparticles and their in vitro antibacterial activity

Abstract

Nanotechnology is broadly defined as the study and development of the chemical physical and natural properties of materials, devices, and structures that differ from those found on a larger scale, and Nano patents are derived from the Japanese language. Zinc oxide nanoparticles are used in a wide-ranging applications, visible light, catalytic actions, ultrasonic, deodorizing, diabetes treatment, cosmetics, lasers, paints, ultraviolet light absorbing constituents, rubber industry, catalytic agent for light flattening, and specifically in the medical and pharmaceutical sciences⁷. Curcumin is a useful plant-based material derived from "turmeric" that has the potential to be used in the green synthesis of ZnONPs. This is due to the influence of "polyphenol," which may also result in the formation of ZnONPs during the reduction process. Characterization reported Spherical particles with varying size from few nanometers to about 900 nm. The antibacterial activity by disk diffusion method against E. coli (Gram negative), Pseudomonas aerugionsa, Bordetella bronchiseptics & Micrococcus luteus revealed mark able zone of inhibition that declared potent antibacterial activity of Curcumin ZnO NP against gram positive bacteria more than negative ones where Ciprofloxacin was used as standard.