Advancement, applications, and future directions of 3D models in breast cancer research: a comprehensive review

Authors

  • Rahmana Wazir FOST, Department of Biotechnology, University of Central Punjab, Lahore, Pakistan
  • Manam Walait FOST, Department of Biotechnology, University of Central Punjab, Lahore, Pakistan
  • Muzzamil Shehzad Faisalabad Institute of Research, Science and Technology, affiliated with University of Health Sciences, Lahore, Pakistan

Abstract

3D models have popped up as indispensable tools for breast cancer study, they provide a closer
semblance of the multiplex cellular and cancer tissue microenvironment as compared to
ancient 2D cultures. Their utilization in BC research permits a better interpretation of
hemostasis, cell-to-cell, and cell-to-extracellular matrix interactions, differentiation of cells,
and tissue organization. 3D models qualify the exploration of numerous aspects regarding
cancer progression, it also includes invasion of the tumor, cancer metastasis, and drug
resistance, in a way that more precisely contemplates in vivo conditions. Hence, they provided
a precise environment for research as compared to a complex in vivo host cell environment.
This review highlights the importance of different 3D models in BC research, focusing on their
capability to enumerate complex disease physio-pathological features. This review explains
the variety of 3D models utilized in BC research, encompassing Multicellular Tumor
Spheroids (MCTS), Three-Dimensional (3D) bioprinting, Organoid Models, Microfluidic
technologies, Organ on chip models, 3D hydrogel models and in silico approaches for BC,
challenges and future of 3D models.

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Published

2023-09-30

How to Cite

Wazir, R., Walait, M., & Shehzad, M. (2023). Advancement, applications, and future directions of 3D models in breast cancer research: a comprehensive review. International Journal of Natural Medicine and Health Sciences, 2(4), 12–20. Retrieved from https://journals.iub.edu.pk/index.php/ijnms/article/view/1371

Issue

Vol. 2 No. 4 (2023): International Journal of Natural Medicine and Health Sciences

Section

Articles

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Copyright (c) 2023 International Journal of Natural Medicine and Health Sciences

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