Colorectal Cancer in Pakistan: genetic, molecular, and epidemiological perspectives

Authors

  • Rao Zubair Khaliq Centre of Excellence in Molecular Biology (CEMB), University of the Punjab, Lahore, Punjab, Pakistan.
  • Abdul Hameed National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Punjab, Pakistan.
  • Tahrim Tahir University of Okara, Okara, Punjab, Pakistan.
  • Ahmad Abbas University of Okara, Okara, Punjab, Pakistan.

Abstract

Colorectal cancer (CRC) stands as a major health concern globally, with a notable impact in Pakistan. The epidemiology of CRC in this region reveals a higher prevalence in men and an increasing incidence in younger age groups. Risk factors contributing to CRC encompass a blend of lifestyle choices and genetic predispositions. The genetic and molecular pathways which are crucial to understanding of CRC pathogenesis include the CpG Island Methylator Phenotype (CIMP), Chromosomal Instability (CIN), and Microsatellite Instability (MSI). The challenge of late-stage diagnosis due to limited screening is a critical factor affecting survival rates in Pakistan. Compared to higher incidence rates in developed countries, the situation in Pakistan underscores the need for region-specific research and healthcare strategies. The review provides an in-depth analysis of CRC's epidemiology, risk factors, and molecular mechanisms in Pakistan, highlighting the urgent need for enhanced research, prevention, diagnosis and treatment methods in the region.

Author Biography

Tahrim Tahir, University of Okara, Okara, Punjab, Pakistan.

Department of Biotechnology, University of Okara

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Published

2023-12-31

How to Cite

Khaliq, R. Z., Hameed, A., Tahir, T., & Abbas, A. (2023). Colorectal Cancer in Pakistan: genetic, molecular, and epidemiological perspectives. International Journal of Natural Medicine and Health Sciences, 3(1), 13–17. Retrieved from https://journals.iub.edu.pk/index.php/ijnms/article/view/1566

Issue

Vol. 3 No. 1 (2023): International Journal of Natural Medicine and Health Sciences

Section

Articles

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Copyright (c) 2024 Rao Zubair Khaliq, Abdul Hameed, Tahrim Tahir, Ahmad Abbas

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