Analysis of the capability of IgG antibodies and receptors with their relationships to food tolerance and autoimmune disorders

Authors

  • Awais Ali Department of Biocehmistry, Abdul Wali Khan University Mardan. Mardan-23200, Pakistan
  • Uzma Manzoor Department of Clinical Biocehmistry, COMSAT University Sahiwal, Pakistan
  • Syed Luqman Ali Department of Biocehmistry, Abdul Wali Khan University Mardan. Mardan-23200, Pakistan
  • Reema Nousheen Department of Medicine, Shadan Institute of Medical Sciences, Hyderabad- 500008, India
  • Waseef Ullah Department of biocehmistry, Abdul wali khan university Mardan. Mardan-23200, Pakistan
  • Kashif Adil Department of biocehmistry, Abdul wali khan university Mardan. Mardan-23200, Pakistan

DOI:

https://doi.org/10.52461/ijnms.v3i1.2455

Abstract

Recent research has shed light on a particular IgG mediated reaction that may serve as a natural
defense mechanism against food-borne infections. The immune system has an unmistakable
boundary when it comes to self-antigen intolerance. Tolerance establishment and maintenance
to dietary antigens are critically impacted by IgG. Mutable auto immunological diseases are
characterized by polyclonal antibodies and autoreactivity of B and T cells. Based on
differences in the hinge area and the constant section of heavy chains, IgG subclasses are
classified as IgG1, IgG2, IgG3, and IgG4. The ratio of IgG subclasses in serum is thought to
be diagnostic of a particular autoimmune disease that causes autoantigens, according to various
pieces of evidence. Through their regulation of interactions amongst Immunoglobulin Fcgamma receptors, and complement, several studies have examined blood levels of IgG
subclasses throughout the course of various illnesses, suggesting that they may play a
pathogenic role. A high level of sub-neutralizing and cross-reactive non-neutralizing
antibodies against viruses might accelerate the course of action of certain viral infections
through a process known as antibody-dependent enhancement (ADE). The increased
pathogenicity in ADE in vitro models has been linked to viral entry through the Fcγ receptor
(FcγR) instead of the canonical viral receptor. Various viral diseases, including as dengue
virus or SARS-CoV, are investigated in relation to FcγR engagement.

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Published

2023-12-31

How to Cite

Ali, A., Manzoor, U., Ali, S. L., Nousheen, R., Ullah, W., & Adil, K. (2023). Analysis of the capability of IgG antibodies and receptors with their relationships to food tolerance and autoimmune disorders. International Journal of Natural Medicine and Health Sciences, 3(1), 25–32. https://doi.org/10.52461/ijnms.v3i1.2455

Issue

Vol. 3 No. 1 (2023): International Journal of Natural Medicine and Health Sciences

Section

Articles

License

Copyright (c) 2024 Awais Ali, Uzma Manzoor, Syed Luqman Ali, Reema Nousheen, Waseef Ullah, Kashif Adil

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